Azoles are prominent scaffolds in pharmaceutical arena. In fact, medicinal properties of azole and benzazole containing compounds include anticancer, antimicrobial, and antioxidant. Some of the drugs Inthomycin C, Oxaprozin, Tiazofurin, Dacarbazine, Tipifarnib, Albendazole, Febendazole, Omeprazole possess azole / benzazole moiety. Realizing the importance of azoles and benzazoles, it is planned to conjugate these two ligands as heteroaryl substituted urea derivatives and to study their antimicrobial activity. The results pertaining to these aspects will be discussed.

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Amide unit is a privileged structural motif and is a constituent of proteins, natural products and pharmaceuticals.Amongst different heterocyclic scaffolds, azoles and pyrimidines are the prominent entities in pharmaceutical arena. The biopotency of these heterocycles have triggered to synthesize a variety of heteroaromatics-azoles linked with pyridines by amino acetamide group. The target molecules-azolylaminoacetamidopyrimidines were prepared by the reaction of methyl azolylglycinate with pyrimidinyl-2-amine in the presence of DMAP and triethylamine in dichloromethane under ultrasonication.The lead molecules were evaluated for antimicrobial activity. The results on these aspects will be discussed.