The article provides information on the determination of the bacteriostatic and bactericidal activity of the disinfectants AQUAdes-NUK 5, Desinfexan and IncimaxxDES in relation to Salmonella typhimurium. The activity of disinfectants AQUAdes-NUK 5, Desinfexan and IncimaxxDES in the framework of determining their bactericidal activity and the severity of bacteriostatic properties was studied by the method of serial dilution, in which daily cultures of Salmonella typhimurium were used. During the research, the minimum concentrations were established at which bactericidal activity was manifested and a pronounced bacteriostatic effect was obtained. After processing the results obtained, we can conclude that the disinfectant AQUAdez-NUK 5 has a bacteriostatic effect on S. typhimurium at a concentration of 0.004%, but a pronounced bactericidal effect occurs only at a concentration of 0.008%. The degree of effect of IncimaxxDES disinfectant on S. typhimurium characterizes this agent as highly effective for disinfection when contaminated with this pathogenic microorganism. In particular, the bacteriostatic effect could be ascertained when the concentration reached 0.002%, the bactericidal effect at the 0.008% concentration, which indicates the high efficiency of the drug.Disinfexan has a pronounced antimicrobial effect, the bactericidal effect on S. typhimurium occurred at a similar dilution of 0.002%, and the bacteriostatic effect was manifested at lower dilutions of 0.0005%. In studies on the setting of control during bacteriological examination of the means AQUAdes-NUK 5, IncimaxxDES and Desinfexan, the growth of microorganisms was observed in test tubes into which the culture of S. typhimurium was enucleated. There was no growth in a test tube with the addition of distilled water to the BCH. The results obtained prove that the new disinfectant AQUAdes-NUK 5 exhibits pronounced bactericidal activity against the test microorganism S. typhimurium.