Ovarian cancer representing the most lethal gynecologic malignancy escapes from the efforts to manage the disease. We reviewed the current state of the research considering three main concepts on origin of ovarian cancer including epithelialmesenchymal transition, secondary origin from Müllerian system and cancer stem cell hypothesis. Cytogenetic and molecular characteristics of ovarian cancer are focused particularly on microRNA expression studies revealing huge potential in recent years, although other transcriptomic, proteomic, epigenetic, epidemiologic and immunological factors are touched upon, too. Routine and investigated diagnostic and treatment methods are outlined and several factors revealed to be associated with prognosis of the disease. Despite the huge progress on elucidating factors involved in ovarian cancer carcinogenesis, still remains urgent need to improve both the diagnostics as well as the treatment.

Oral communication abstracts(p < 0.05). Post-operative survival was better in the prenatal group (p < 0.05). At long-term follow up re-intervention-free survival was longer in the prenatal group (p < 0.04). Overall survival at maximum follow up was 92% in the prenatal compared to 84% in the postnatal group (p < 0.18). Conclusions: Prenatal detection of isolated congenital heart defects improves the short and longterm prognosis of the affected children.

No abstract

No abstract

No abstract