Fifty four schizophrenic patients, diagnosed a s per Research Diagnostic Criteria, were studied for the imn~unoglobulin profiles. The patients were given neuroleptics and the influence 01' neuroleptics on serum immunoglobulins IgG, IgA and IgM wds assessed by comparing the pretreatment and post-treatment immunoglobulin levels. A significant elevation of IgG levels was found in paranoid schizophrenics alter neurolptic treatment. IgA and IgM showed no alterarion The etiological implications are discussed.

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