The transient receptor potential melastatin subfamily member 2 (TRPM2), a thermo and reactive oxygen species (ROS) sensitive Ca2+-permeable cation channel has a vital role in surviving the cell as well as defending the adaptability of various cell groups during and after oxidative stress. It shows higher expression in several cancers involving breast, pancreatic, prostate, melanoma, leukemia, and neuroblastoma, indicating it raises the survivability of cancerous cells. In various cancers including gastric cancers, and neuroblastoma, TRPM2 is known to conserve viability, and several underlying mechanisms of action have been proposed. Transcription factors are thought to activate TRPM2 channels, which is essential for cell proliferation and survival. In normal physiological conditions with an optimal expression of TRPM2, mitochondrial ROS is produced in optimal amounts while regulation of antioxidant expression is carried on. Depletion of TRPM2 overexpression or activity has been shown to improve ischemia–reperfusion injury in organ levels, reduce tumor growth and/or viability of various malignant cancers like breast, gastric, pancreatic, prostate, head and neck cancers, melanoma, neuroblastoma, T-cell and acute myelogenous leukemia. This updated and comprehensive review also analyzes the mechanisms by which TRPM2-mediated Ca2+ signaling can regulate the growth and survival of different types of cancer cells. Based on the discussion of the available data, it can be concluded that TRPM2 may be a unique therapeutic target in the treatment of several types of cancer.

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Brownlowia tersa (L.) (Family: Malvaceae), has been used traditionally to treat inflammation, pain, diarrhea, allergic reaction etc. The aim of the recent study is to investigate the ethanolic extract of Brownlowia tersa (L.) stem for its anti-hyperglycemic and anti-allergic activity as well as to identify the phytochemicals constituents. Blood glucose level in mice, in anti-hyperglycemic activity, evaluated by OGTT (oral glucose tolerance test) considerably reduced by the extract at both dose 250 and 500 mg/kg b. wt. The extract also decreased significantly the allergic-like symptoms like sneezing, scratching, and nasal score induced by TDI in mice model. The count of WBC (total and differential) in both blood and Bronchoalveolar lavage (BAL) fluid were also reduced in the extract treated group. In qualitative phytochemical investigation, existence of different bioactive phytochemicals like alkaloids, flavonoids, steroids and tannins were observed. So the investigation suggests the anti-hyperglycemic and antiallergic activity of B. tersa stem extract due to the availability of one or more active metabolites in it.

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