The NW-SE trending grabens of Sers-Siliana, located in the Central Tunisian Atlas, show a peculiarity, compared to adjacent grabens, which comes from the existence of an early Miocene sedimentary gap. This paper discusses the structural evolution of these grabens, during the Neogene-Quaternary episode, which have been poorly studied in previous studies. To better understand the chronology of the two grabens, a set of direct and indirect pieces of evidence are given in order. The results show that the collapse is of Aquitanian-Tortonian age which is synchronous with the regional collapse of the Alpine chain foreland grabens. In addition, our field observations show that the E-trending faults affect the incompetent materials (marls) and assured the mechanical junction between these two grabens. The chronology of tectonic events, during the Neogene-Quaternary time, in the Sers-Siliana area coincides with that described at the regional scale for the Tunisian Atlas domain, allowing a better understanding of the role played by the convergence between African and Eurasian plates.