Hyperbaric formulation of local anesthetic solutions have some advantages over plain solutions. The hyperbaric solutions are used in various fields of medicine due to their properties. The aim of this study was to assess the awareness about hyperbaric prilocaine among dental students.This study included 150 dental students in a dental hospital during the month of December 2019. Pre tested questionnaire was distributed among the students through an online link. Data was tabulated and results were obtained.Descriptive and chi square statistics were performed.Out of 150 patients, 6 students (44%) were under 18-20 years and 84 students (56%) were under 21-25 years age groups. Out of 150 students ,87 students (58%) were males and 63 students (42%) were females. On analysing the awareness of hyperbaric prilocaine among students, 88% had known about hyperbaric oxygen and 12% were not aware about hyperbaric prilocaine. There was a significant association between age groups and awareness among dental students (p<0.05) while no statistically significant was found between gender and awareness among dental students (p>0.05). Within the limitations of the present study, the awareness about the uses and properties of hyperbaric prilocaine was moderate.