We present a case of a sixty-year-old female who presented with sudden onset of painless loss of vision in one eye due to a perforated corneal ulcer, following three months of treatment with gefitinib, a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor for metastatic adenocarcinoma of the lung with confirmed EGFR gene mutation. The eye did not show any sign of infection or inflammation and had no associated lid problems to account for the development of corneal ulceration. The patient went on to have a corneal graft surgery but postoperatively developed corneal graft melt. This paper aims to raise awareness among ophthalmologists and oncologists of the probable association between gefitinib and corneal ulceration.

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Gastro-duodenal injury associated with intake of 100-325 mg aspirin daily Morrell, F.R.C.S., who performed a gastrostomy which revealed multiple gastric erosions, the largest of which were underrun. Aspirin was discontinued and she had no recurrence of bleeding. The lesson from this case is that the modest doses of aspirin currently recommended for ischaemic heart disease2 and for transient ischaemic attacks3 also carry the risk of life-threatening gastropathy, even in patients with hypochlorhydria.

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