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Currently, the rabies situation remains grave in the Russian federation. Almost all country regions face the activation of natural rabies foci. The number of disease cases among wild carnivores is growing, and domestic and farm animals are getting infected. Insufficient anti-rabies vaccination of animals and poor vaccine effectiveness control are the reasons behind the high incidence rate. Rabies control involves preventive immunization of farm and domestic animals, catching stray dogs and cats, oral vaccination of wild animals, and wildlife management measures. The paper describes the epizootic situation of rabies in the Republic of Tatarstan from 2010 to 2020. The study revealed a correlation be-tween incidence cases with preventive measures. The obtained data indicate that since 2016, rabies' epizootic situation has dramatically changed for the better in the Republic of Tatarstan. The change is due to timely quarantine and veterinary preventive measures. The incidence of rabies among farm animals has been minimized. Also, as the number of vaccinated livestock and domestic (cats and dogs) animals, as well as wild animals, increased 2,9 fold over the past years, the Republic of Tatarstan has managed to reach a significant immunisation level, thus preventing the spread of the disease and reducing the incidence of rabies.