It was studied neurohumoral and immunoinflammatory disorders in 184 patients with Q-myocardial infarction (153 with metabolic syndrome and 31 without metabolic syndrome). It was found that acute period of Q-myocardial infarction in patients with metabolic syndrome is associated with a decrease in serum insulin-like growth factor and activation of a range of neurohormonal and immunoinflammatory factors: C-reactive protein, interleukin-1α, interleukin-6, tumor necrosis factor-α, endothelin-1, plasminogen activator inhibitor-1, which have close correlations with the components of the metabolic syndrome.