Grave’s disease is the most common cause of hyperthyroidism. Antithyroid drugs are usually well tolerated in majority of patients but serious side effects in the form of allergy, agranulocytosis, aplastic anaemia, vasculitis, hepatitis etc occur in 3 – 12% of treated patients. Carbimazole is extensively used as the drug of choice except in pregnancy, where propylthiouracil is preferred. We report a case of 35 year old female patient with Grave’s disease, who developed cholestatic jaundice following administration of carbimazole for 2 months. Symptoms and laboratory abnormalities subsided on withdrawal of carbimazole and Grave’s thyrotoxicosis was managed with propranolol and propyl-thiouracil.

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Background: Alcohol intake is most widely used social drink worldwide. Chemically it is ethyl alcohol which is produced by fermentation. Habitual and regular intake of alcohol causes damage to every system of our body and is associated with HBV, HCV and other viral infections. Methods: In this study involving 194 patients of ALD, we found HBsAg was positive in 4.6% of patients of ALD. Most of the cases had developed cirrhosis and its complications. Results: Of all HBsAg positive patients, 44.4% presented with gastrointestinal bleeding and 44.4% with hepatic encephalopathy. The mean value of SGOT and SGPT were significantly higher in HBsAg positive patients as compared to HBsAg negative patients. Conclusion: The study concluded that alcoholics are more prone to infection with Hepatitis B as compared to non alcoholics and are more prone to develop cirrhosis and its complications.

Zika virus is a mosquito borne flavivirus that is an emerging pandemic and public health emergency. Previously limited to sporadic cases in Africa and Asia, the emergence of Zika virus in Brazil in 2015 heralded rapid spread throughout the Americas. "The Ministry of Health and Family Welfare, Government of India (MoHFW) reported three laboratory-confirmed cases of Zika virus disease in Bapunagar area, Ahmedabad District, Gujarat State, India," the global health body said in a statement. India has strengthened its surveillance system in the past few years to detect and contain new infections. Only three Zika cases have been detected in around 50,000 tested so far, a senior Health Ministry official said.

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