1-(4- Bromo -1-hydroxynaphthalen-2-yl)-ethan-1-one was prepared by refluxing 4- bromonaphthalen-1-ol with glacial acetic acid in presence of fused ZnCl2. By condensing 1-(4- bromo -1-hydroxynaphthalen-2- yl)-ethan-1-ones with 4- methoxy benzaldehyde, to prepared by 1-(4- bromo -1- hydroxynaphthalen-2-yl)-3-(4-methoxy phenyl)-prop-2-en-1-one were synthesized.1-(4- bromo -1- hydroxynaphthalen-2-yl)-3-(4-methoxy phenyl)-prop-2-en-1-one, urea and concentrated HCl in DMF were added and refluxed. Cool and pour in crushed ice. Treat it with cold NH4OH solution to obtain titled compounds. The compounds thus synthesized have been characterized by physical and spectral data. All of these titled synthesized compounds have been screened for antimicrobial study and are found to possess excellent antimicrobial activities.