It is a rare case of a 53 year old female patient with three different malignancies occurring metachronously; papillary carcinoma of the thyroid followed by malignant phyllodes tumor of her left breast and finally acute myeloid leukaemia. As the patient in the report had received postoperative local ionising radiation treatment seven years prior to her development of acute myeloid leukaemia, the role of the exposure to ionising radiation as the causative mechanism in the development of this malignancy cannot be completely ruled out. This case report suggests that patients who have had a first cancer successfully treated are at higher risk of developing a second or even a third subsequent cancer; therefore, long term regular followup is essential for successfully treated cancer patients for the early diagnosis of the development of subsequent malignancies and their effective treatment.

No abstract

Ectopic Cushing’s syndrome (ECS) is a rare para neoplastic syndrome that occurs in patients with small cell lung cancer (SCLC). Because of the aggressive nature of the syndrome and its atypical features, ECS in small-cell lung cancer is difficult to diagnose and has a poor prognosis. We report a case of a 53-year-old male patient who presented with severe proximal muscle weakness in all4 limbs, and loss of appetite. He had no chest symptoms. The patient was eventually diagnosed with stage IV primary small-cell lung cancer with ECS and survived only one week following diagnosis. We have conducted a review of relevant published articles.