Our research is focused on study of changes in the intima-media vascular wall of patients suffering from hypertensive disease as well as patients suffering from hypertensive disease and coexistent extrasystole. We examined 120 patients (42 men and 78 women) between the ages 27 to 81 suffering from hypertensive disease of the II stage as defined by the Ukrainian Association of Cardiologists and extrasystoles (more than 30 episodes per hour of research) of different topography and 30 persons (13 men and 17 women) suffering from hypertensive disease of the II stage between the ages 30 to 76 without rhythm disturbance. The first clinical group was formed of 54 (45%) patients suffering from repeated supraventricular extrasystoles. The second clinical group was formed of 42 (35%) patients suffering from repeated ventricular arrhythmia. The third group was formed of 24 (20%) patients suffering from both repeated supraventricular extrasystoles and ventricular extrasystoles. The results of treatment demonstrate that the existence of repeated supraventricular extrasystoles and ventricular extrasystoles in patients suffering from hypertensive disease of the ІІ stage in contrast to patients without arrhythmia and repeated supraventricular extrasystoles is associatesd with severer vascular dysfunction, which is defined by signs of rather high rigidity of the large arteries (significant reduction of original size of brachial artery diameter), severer defects of endothelium-dependant vasodilation (reduction of increment value of brachial artery diameter during the test with decompression, reduction of periodicity of registration of normal reaction and increase of paradoxical vasoconstriction of the brachial artery during the test with decompression) and significant reduction of general vasodilational potential, increase of frequency of cases with dissociation in the nature of endothelium-dependant and endothelium-independent reaction of the brachial artery. The latter changes were registered in 90 (60.0%) of examined patients, the most frequent of their variants were: 1) reduced reaction of the brachial artery for decompression + normal response in the test with nitroglycerine (29.7%) and 2) paradoxical vasoconstriction in response to decompression + reduced reaction on taking nitroglycerine (22.4%).

The significant incidence of hypertensive disease among the Ukrainian population makes the search for new methods of management and treatment of patients suffering from this pathology a matter of high priority. Our research is focused on study of changes of some biochemical parameters in patients suffering from hypertensive disease as well as patients suffering from hypertensive disease and coexistent extrasystoles. Arterial hypertension leads to different structural and functional changes in the cardiovascular system. In many patients these changes may result in rhythm disorders. 120 patients have been examined (42 men and 78 women) between the ages of 27 to 81 (average 59.8) suffering from hypertensive disease of the II stage as defined by the Ukrainian Association of Cardiologists and from extrasystoles (more than 30 episodes per hour of research) of different topography and 30 persons (13 men and 17 women) suffering from hypertensive disease of the II stage between the ages 30 to 76 (average 56.4) without rhythm disturbance). The first clinical group was formed by 54 (45%) patients suffering from repeated supraventricular extrasystoles (SE) (average 62 ± 2 SE per hour of research). The second clinical group was formed by 42 (35%) patients suffering from repeated ventricular arhythmia (VA) (average 37 ± 2 VA per hour of research). The third group was formed by 24 (20%) patients suffering from both repeated SE and VA (average 48 ± 3 SE and 32 ± 3 VA per hour of research). We conducted 24 hours’ monitoring of blood pressure and electrocardiography using the “Dia Card”-system (“Solvaig”, Ukraine) for all patients. This revealed that ventricle extrasystoles and combined extrasystoles in patients with essential hypertension, II stage are associated with more unfavourable changes in 24 hours’ profile of blood pressure. The paper analyses the cardiac arhythmia structure of heart rate variability in patients with arterial hypertension (AH) and extrasystoles. The findings confirmed the presence of desynchronization in the activity of the neurohnmoral system. Thus, different mechanisms of arhythmogenesis were revealed in patients with arterial hypertension. In the results, frequent ventricular and combined extrasystoles were associated with an unfavourable blood pressure profile during 24-hours monitoring as well as higher end-diastolic left ventricular volume, diastolic dysfunction, aortic valve fibrosis, aorta remodeling, endothelial dysfunction and more prominent lipid disorders. Supraventricular extrasystoles were associated with hypertriglyceridemia, left ventricular diastolic dysfunction and left atrium enlargement.