In the Republic of Belarus, as well as around the world, there is a continuous search for ways and methods of efficient struggle against the varroatous invasion of bees, however, no significant decisions are found in this struggle. In the context of this problem, scientific studies were conducted on development of modern technology of beekeeping on the background of spread varroatous invasion. Technological methods are proposed in the fight against varroatous invasion of bees, proving efficiency of the joint use of zoothechnical, biological and mechanical methods of combating the Varroa tick. It has been shown that purposeful rearing and selection of the drone brood reliably reduces the tick contamination of bee families by 5.7-17.4%. It has been substantiated that the use of intraulic pollen collector significantly reduces the number of ticks in the bees families, especially in the early spring period, when the ticks are mainly located on bees and are especially vulnerable to mechanical impact. The use of the feeding frame allows to purposefully obtain, conveniently and easily select the drone brood, and along with the drone brood, remove the Varroa tick form the bee nest. The use of the developed technology will allowed to reduce the number of tick, obtain additional products in the form of a homogenate of trutone larvae. Such system will increase the preservation of bee families, productivity of honey harvest and, as a result, increase the profitability of beekeeping production, as well as the effectiveness of pollination of entomophilic agricultural crops and their yield.