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We studied the effect of lauric acid on transdermal penetration of phenazepam in vivo. It was found that treatment with lauric acid 3-fold increased the maximum anticonvulsive effect of phenazepam applied in a transdermal therapeutic system in comparison with the control. Study of the pharmacokinetics of phenazepam transdermal therapeutic system showed its higher bioavailability in the presence of lauric acid (f=0.9).

UDC 535:530.182 + 535.399 We have studied the nonlinearity of the refractive index at a wavelength of 1.08 µm for optical lead silicate and lead phosphate tellurite glasses of different compositions. We have shown that the nonlinear refractive index n 2 increases as the lead content increases in lead silicate glasses and as the tellurium content increases in lead phosphate tellurite glasses, where the latter are typically have higher values of n 2 , as high as 24⋅10 -13 cgs units (47⋅10-16 cm 2 /W), and lower Rayleigh losses. We have established a correlation between the nonlinear refractive index and the microstructure of the studied glasses. The highly nonlinear glasses are distinguished by extensive fluctuations in the heavy metal oxide concentration which are "frozen" during cooling of the glass melt.Key words: nonlinear refractive index, lead silicate glass, lead phosphate tellurite glasses, Rayleigh scattering, "frozen" density fluctuations, Landau-Placzek ratio.Introduction. The nonlinear optical properties of glasses have attracted the attention of researchers for many years because of the practical importance of taking into account the nonlinear properties of optical materials when designing specific optical elements. For example, glasses for making active elements of high-power lasers should be characterized by a low nonlinear refractive index n 2 , while glasses with high nonlinear refractive index are of interest for devices to control optical radiation. In this case, it becomes considerably important to theoretically describe the nonlinear refractive index and to obtain expressions for calculation of n 2 that are convenient for practical application. Usually glasses are considered as homogeneous media with nonlinear properties that are functions of macroscopic parameters of the medium such as the linear refractive index n 0 , the bandgap width, etc. [1, 2]. Miller's rule [3] established the relationship between the first-order and third-order nonlinear susceptibilities:

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