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PREVALENCE OF OSTEOGENESIS Biology and Biotechnologies, Southern Federal University, 6 Federal state budgetary Institution «Central Research Institute N.N. Priorova» Health Ministry, Moscow,.ru The results of the genetic and epidemiological study of imperfect osteogenesis among the population of 12 districts of the Rostov Region conducted in the period 2006 -2016 are presented. The study was conducted according to the protocol developed in FSSBI "RCFMG". Was study population of 12 districts Rostov region. The number of the surveyed population was 497.460 people (the general population by more than 90 % is represented by Russian). Primarily, 30 patients from 19 families with clinical manifestations of imperfect osteogenesis were identified. The total prevalence of imperfect osteogenesis in the Rostov region initially amounted to 1: 16582 (or 6.03 per 100,000 population). Later, one family (3 patients), whose clinical description, as well as the complexity of differential diagnostics of gnathodiophysial dysplasia, in the clinical picture of which the imperfect osteogenesis was the leading symptom in patients, was excluded from this group, which affected the prevalence of imperfect osteogenesis, which finally Were 1: 17766 (or 5.63 per 100,000 population).