The aim of our investigation was to evaluate the humoral response to natural SARS-CoV-2 infection and to two COVID-19 vaccines (BNT162b2 Pfizer-BioNTech and Beijing/Sinopharm BBIBP-CorV) in our cohort of PwMS under high efficacy disease modifying therapies (DMTs), cladribine and alemtuzumab. Methods: Twenty two PwMS treated at the Clinic of Neurology, in Belgrade, who developed COVID-19 and/or were vaccinated against SARS-CoV-2, during treatment with cladribine and alemtuzumab, were included. Out of 18 patients treated with cladribine, 11 developed COVID-19, and 11 were vaccinated against SARS-CoV-2 (four with mRNA vaccine, 7 with Sinopharm). Four MS patients under alemtuzumab were vaccinated against SARS-CoV-2; three with mRNA, and one with Sinopharm vaccine. SARS-Cov-2 IgG response was measured using ELISA anti-spike protein-based serology (INEP, Belgrade, Serbia). Results: All 7 patients under cladribine treatment who suffered from COVID-19, developed IgG antibodies, 2.0-5.5 months after last symptoms. All four (100%) patients under cladribine who were vaccinated with Pfizer-BioNTech vaccine, and three out of seven (42.9%) vaccinated with Sinopharm, developed antibodies. All 4 patients under alemtuzumab developed antibodies after vaccination. In all cases, seroprotection occurred, irrespective of timing of vaccination and absolute lymphocyte count. Conclusion: Our findings in a small number of highly active PwMS in whom, lymphodepleting, immune reconstitution therapies, were applied in order to successfully manage MS, indicate that in a number of these patients it was possible to develop at the same time seroprotection in these patients after COVID-19 vaccination in these complex circumstances.

Baseline functional status and severity of WMH and development of cognitive decline predict the occurence of late-onset depression in patients with SVD.

On average, radon concentrations are substantially higher in schools in villages than in schools located in towns (double,on average). Annual radon concentrations exceeding 300 Bq/m3 were found in 5% of primary schools (generally on ground floors of schools in villages). The considerable variability of radon concentration observed between and within floors indicates a need to monitor concentrations in several rooms for each floor. A single radon detector for each room can be used provided that the measurement error is considerable lower than variability of radon concentration between rooms.

No abstract

Multiuser multiple-input-multiple-output (MIMO) wireless systems have great potential in improving information rate, diversity and resistance to against interference. The primary objective of this paper is to derive for broadband signaling a new iterative frequency domain (FD) multiuser MIMO signal detection technique for joint-over-antenna (JA) detection. The proposed detector is based on soft-cancellation and minimum mean square error (MMSE) filtering, followed by maximum a posteriori probability (MAP) detector to detect several of each users transmit antennas. The purpose of jointly detecting several transmit antennas is to preserve the degrees of freedom (DoF) for MMSE. Computational complexities with FD and its time domain (TD) counterpart are evaluated in this paper, and it is shown that FD requires significantly lower complexity than TD. Numerical results show that JA significantly outperforms the receiver that detects transmit antenna signals antenna-byantenna (AA). The proposed iterative FD JA technique achieves larger performance gains compared to AA when the total number of transmit antennas is larger than the number of receiver antennas, as well as in the presence of spatial correlation.Index Terms-Multiuser MIMO, spatial multiplexing, turbo coding, iterative processing, frequency domain equalization.