Background: ISS, GAP scores and the cytokines IL-6 reflects the severity of an injury. Recently levels of the cytokine IL-6 are the best biomarker that reflects the severity of the trauma. There has been no research on the relationship between ISS and GAP scores with IL-6 cytokine level in fracture patients with multiple traumas. This study is a cross-sectional observational study. Methods: All fracture patients treated at Sanglah Emergency Unit started in January 2016 that met the inclusion criteria became sample. At sample, we calculate ISS and GAP scores and took blood samples for examination of IL-6 cytokine level. Bivariate analysis performed by Chi-square to determine the relationship between ISS and GAP score with IL-6 cytokine level. Results: Samples were 60 patients from January to April 2016. In this study, the correlation between the ISS and IL-6 cytokines was 0.05 (p=0.705), whereas the correlation between GAP scores and IL-6 cytokines was -0.399 (p=0.002). Conclusions: In this study there was positive correlation that weak and not significant between the ISS and IL-6 cytokines and there was a negative correlation that had moderate strength and significant between GAP scores and IL-6 cytokines.