Recently, the preparation of the endometrium for embryo transfer, namely the achievement of optimal thickness and receptivity of the endometrium, the prevention of unsuccessful attempts to implant embryos, is gaining more and more attention among doctors in the field of reproductive medicine. Since cryptocycles of embryo transfer preparation are often discontinued in the practice of a reproductive physician due to insufficient endometrial thickness, high doses of estrogen and negative IVF results provided the satisfactory condition of the endometrium on the day of transfer and quality of the embryos. The article briefly presents the views on the effectiveness of PRP therapy of the endometrium in the protocols of preparation for embryo transfer. The main mechanisms of the effect of platelet-rich blood plasma on the endometrium are elucidated. The positive effect of this technique on regeneration, increase in thickness and improvement of endometrial receptivity is proved. Conclusion. PRP-therapy of the endometrium is a modern, affordable, effective and safe method of treatment of thin and damaged endometrium in reproductive medicine.