The study examined the effect of an analog to N-terminal nociceptin fragment AcOH×Phe-Gly-Gly-Phe-NH(2) on the behavior of albino rats. This tetrapeptide (5 μg/kg intraperitoneally) significantly enhanced motor and exploratory activity in mature rats and in 42-day pups and produced opposite effects in 21-day rat pups, which attests to the complex dynamics of maturation of nervous structures involved in the realization of nociceptin action.

267 scent HDL. The content of total serum Ch dropped by 38% (p<0.01) and by 41% (p<0.01) after the administration of compound II and compound I, respectively. However, the level of c~-Cli did not drop, and in the case of compound II it even rose 22%, i.e., the drop of total Ch occurred due to LDL and VLDL Ch. Both test compounds increased the content of Ch in the liver, whereas accumulation of TG was observed only in the case of compound I (Table 2).Thus, the effect of compounds I and II on serum LP and on the content of Ch in blood serum and in the liver surpasses that of estradiol, which does not normalize the LP spectrum in ovariectomized animals and even alters it adversely in experimental animals. Compound II possesses a less pronounced hypolipidemic activity in comparison with compound I; however, its effect on the serum LP spectrum is more favorable.

The behavior of CBA mice in the hole-board test and elevated plus maze was studied after intraperitoneal injection of skatole leading to destruction of the epithelium in the main olfactory system. Locomotor and exploratory activity and degree of anxieties were low in intact mice. Anosmia was accompanied by an increase in orientation and exploratory activities and degree of anxiety.

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