Objective. To analyze the psychological nursing effect of patients with gynecological malignant tumor. Method. A total of 104 patients with gynecological malignant tumor receiving chemotherapy in our hospital from December 2019 to November 2020 were selected and randomly divided into observation group and control group with 52 cases each. Patients in the control group were treated with routine nursing of gynecological malignant tumor chemotherapy. The observation group applied psychological nursing methods on the basis of the control group, and psychological status, quality of sleep, quality of life, treatment coordination, and adverse reactions were compared between the two groups. Results. There was no difference in anxiety and depression scores ( P > 0.05 ), the postintervention score was lower than the preintervention score, and the reduction was more significant in the observation group ( P < 0.05 ). After intervention, PSQI scores of the two groups of subjects were significantly lower than before intervention ( P < 0.05 ), subjects in the observation group were significantly lower than those in the control group, and the difference was statistically significant ( P < 0.05 ). After intervention, the total score of FACT-B scale was significantly higher in the observation group than in the control group, and the difference was statistically significant ( P < 0.05 ). After the implementation of psychological nursing, the degree of tumor treatment cooperation of observation group was higher than the control group ( P < 0.05 ). After intervention, there was no statistically significant difference in hematology, allergic reaction, or hair loss between the two groups ( P > 0.05 ). The incidence of gastrointestinal and neurological adverse events in the observation group was significantly lower than that in the control group, and the difference was statistically significant ( P < 0.05 ). Conclusion. The psychological state of patients with gynecological malignant tumor mainly included anxiety and terror and so on. Through psychological counseling, it could effectively alleviate the abovementioned bad psychology, improve the cooperation of patients with tumor treatment, and reduce the occurrence of patients’ adverse reactions.