The present study attempted to compare neurotic patients and normal (non-neurotic) individuals with respect to their personality pattern and quality of life. For the said purpose a group of 50 neurotic patients were purposively selected from the OPD of Psychiatric department of Tripura Medical College, Hapania. Another matched group of normal persons was also purposively selected from West District. Data were collected by using NEO-Five Factor Personality Inventory developed Paul and McCrae (2008) and Quality of Life Scale-WHOQOL-BREF (1991). Data analysis revealed significant difference between neurotic and normal individuals with respect to their personality pattern and quality of life. However, insignificant difference was observed between them with respect to openness to experience dimension of their personality.