The demand for non-invasive skin-tightening techniques is continuously on the rise, as now numerous patients seek safe and effective alternative body, neck, and facial aesthetic surgical procedures. Microfocused ultrasound (MFU) has been recently introduced as a novel energy modality for skin rejuvenation to produce a more significant wound healing response at various levels, including strong collagen remodeling and long-lasting clinical response. This literature study was intended to find the role and efficiency of using micro-focused ultrasound therapy in male and female patients aged 35-65. A total of 139 articles were extracted from the PubMed and Science Direct electronic databases. After a thorough evaluation and following the exclusion and inclusion criteria, 10 full-text articles were relevant to the study. The goal was to analyze and examine the effects and benefits of MFU treatment to improve the skin. In addition, all of the patients were evaluated to report the harms and risks associated with MFU treatment. The literature study results revealed that significant improvements in the overall aesthetics of sagging of the mid and lower face could be accomplished by using a micro-focused ultrasonic treatment plan. Patients report no considerable side effects, and the results were also long-lasting. MFU treatment can activate deeper tissues without causing injury to the epidermis, which sets it apart from all other skin tightening methods. Better improvements rates have been reported by both patients' self-assessment and clinical investigators' evaluation.

Pedophilia is a mental ataxia and psychotic anarchy associated with more sexual interest in prepubescent children. Pedophiles have impaired frontal lobes, hippocampus and amygdala linked with cognitive defects, antisocial and violent behaviour. These pedophiles have abnormal level of testosterone production that causes the sexual urgency in them. Besides psychotherapies, several drugs and pharmacological approaches have been designed for the treatment of pedophiles. Sexual assault and child molestation by these pedophiles is one of the current issue and every country is the victim of these pedophiles and different cases have been reported worldwide as well as in Pakistan. This paper highlights the basic aspects of pedophiles, their mental state, clinical features and different initiatives taken by policymakers to control child abuse.

Many of the deletions and large mutations found in the Omicron version of COVID-19 are identical to those seen in the α, π, β, and δ based VOCs. Such deletions and alterations have long been known to increase the viral risk of transmission and binding ability. Additionally, these changes are anticipated to increase the chances of immunological evasion and antibody secretion. T478K,

Climate change is the utmost crucial challenge of the 21st century with the significant potential to cause human and economic damage. COVID-19 is a global public health emergency that has caused millions of deaths worldwide.1 Studies reported that thorough sanitation practices, safe and clean water, and proper hygiene services are considered the crucial part of protecting the health of humans during the infectious disease outbreaks such as the global COVID-19 outbreak.2

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