The cognition is a very critical process even for animals, enables them to recognize each other, their owner, feeding space requirement and help them in the vital behaviors as mate choice, foraging, on the other hand, the surrounded mobile phone radiation (MPR)and its increased application even for animal farms management and feeding can radiate inside the farms leading to the threaten animals' health especially vital organs so this will reflect negatively on the farm income. Our study aimed to evaluate the effect of some famous historical architectural shapes on cognitive state and spatial memory impairment induced by effects of the mobile phone radiation, (900 MHz) for 8 weeks and possibility to create healthy and high efficient architectural farm designs. Thirty-two (32) Swiss Albino male mice were randomly divided into 8 groups (n = 8), they housed in 4 cages with various shapes. Group I & II housed in a traditional cage, Group I served as a control which did not subject to a mobile phone but groups (II-IV) are exposed to mobile phone radiations. Our result revealed that these changes in architectural shapes as housing in pyramid shape can induce positive effects on cognitive state and spatial memory impairment induced by MPR, it also retains the antioxidant capacity total antioxidant (TAC), malondialdehyde (MDA) and nitric oxide (NO), reduced glutathione (GSH), catalase (CAT) plus it alleviate the neurodegenerative effect of MPR on hippocampus and cortex in histopathology, it concluded that housing under pyramidal architectural shape may have a positive effect on cognition and spatial memory impairment induced by the hazard of electromagnetic waves and this study can be useful for architects and advised to be used in the creation of healthy architecture buildings for either human or animal farms.