Introduction: Diseases of the gallbladder commonly manifest as gallstones and gallbladder cancer. Gallstones constitute a significant health problem in developed societies, affecting 10% to 15% of the adult population 1 . In spite of rising incidence of gall bladder pathologies worldwide, incidence of giant gall bladder is very rare.

Intrinsic endophthalmitis is indeed behavior that causes eye disease that spreads into the bloodstream from a distant primary site. The intraocular disease caused by hematogenous microbial proliferation is known as indigenous endophthalmitis. Extrinsic and intrinsic endophthalmitis are the two types of endophthalmitis that exist.  The presence of an external point of entry is linked to extrinsic endophthalmitis. Intrinsic endophthalmitis is a kind of septicemia caused by a blood-borne infection. Endophthalmitis is a disease of all the inner coating of the eyeball except the sclera and cornea, which is accompanied by substantial, increasing vitreous swelling. Endophthalmitis is a severe ocular crisis with severe visual and general consequences. An exterior injury of the entrance, such as injury, operation, or an inflamed cornea, is the most prevalent route of entry for potential pathogens. Endophthalmitis has a complex etiology, with many pathogenic species and substantial regional heterogeneity. The treatment of endophthalmitis has evolved dramatically during the last century. Endophthalmitis induced by direct inoculation dissemination of pathogenic microbes is a rare occurrence that occurs most commonly in sick or disadvantaged people. Intravenous medication usage, diabetes mellitus, immunological impairment, cancer, prolonged hospitalization, or systemic antibiotic therapy have all been linked to a 0.04 percent incidence rate. Haden described metastatic endophthalmitis in a seriously sick patient with pneumococcal cerebrospinal encephalopathy treated with intravenously anti-meningococcal serum in the 1918 volume of the Journal Ophthalmology. Endogenous endophthalmitis, unlike extrinsic endophthalmitis, needs comprehensive systemic antibiotic treatment. In indigenous endophthalmitis, the illness originates not in the eye but elsewhere in the body. As a result, it is necessary to obtain comprehensive cultures. Patients are sometimes unable to carry out their functions in society or household. As a rest, the person cannot cope financially and socially in his environment. Many social and influential factors are disturbed, and the patients are often depressed. Cosmetically the surgeries are not satisfying. Artificial prosthetics can be used, but they're seldom of minimum functional importance. Such interventions can be helpful for the patient. The focus should be made to deliberately save the patients and not just the cosmetic value of the surgery. Persons with chronic endophthalmitis had more excellent eyesight than people with symptomatic or subacute endophthalmitis. Improvements in eyesight were observed in individuals with persistent or subacute keratitis several months after the surgery more frequently than in people with symptomatic endophthalmitis. Nevertheless, in 40 percent of the overall all instances with an abrupt start, there have been no improvements or even decrease in visual acuity.

Otosclerosis is a temporal bone osseous dyscrasia that causes auditory impairment over time. Aberrant growth of a new bone in the middle ear eventually immobilizes and stops the stapes from oscillating in reaction to sound vibrations, resulting in gradual and persistent hearing impairment. Both ears are generally affected by the disease. Otosclerosis is a rapid occurrence of unexplained facial nerve palsy. With just an estimated prevalence of 15-30 per 100,000, it would be the most prevalent reason for lower motor neuron facial nerve paralysis. There are broadly two types of Otosclerosis, namely histological and clinical Otosclerosis.  A minor incidence of Bell's palsy usually goes away in about a fortnight. It takes to recover from a more severe instance of complete paralysis varies. Among the potential complications are. Multiple sclerosis, Miller-Fisher syndrome, Guillain–Barré syndrome, and autoimmune encephalitis are autoimmune diseases. In patients with otitis media, malignant otitis externa damage to your facial nerve is irreversible. Nerve fiber regrowth is abnormal. When you try to move others, specific muscles may contract involuntarily (synkinesis) – for example, when you grin, the eye on the afflicted side may shut. Due to prolonged dryness and scratching of the transparent protective coating of the eye (cornea), the eye becomes wholly or partially blind. Patients report fast and increasing symptoms over a day to a week, with a 72-hour maximum severity. One-half of the face will be weak, resulting in eyebrows, forehead, and mouth angle instability. The incapacity to shut the afflicted eyelid or lip on the affected side is a common symptom. A partial or total weakening of the forehead is the most apparent physical exam finding. If the integrity of the forehead is preserved, a significant reason should be looked into.  Most of the cases of Otosclerosis have idiopathic or unknown causative agents. In some patients with Otosclerosis, a sponge-like bone grows abnormally in the middle ear chamber. Because of this expansion, the ear bones cannot vibrate in response to acoustic pressure.