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Background: Aim of the study was to assess the sleep quality among medical students and explore its relation to many variables as BMI, smoking and chronic diseases.Methods: A descriptive cross-sectional study, conducted among medical students at Ibn Sina national college, Jeddah, KSA. This study was approved by Research Center. A total of 408 participants; Participants are who admitted to hospital for last two days, pregnant and who under 18 years were excluded. We consider p value=0.05 as significant statistically and our confidant interval (CI) is 95%. We used bivariate and univariant variables, for categorical variables we used Chi-square and Fisher exact test.Results: The participants’ mean age was 22.6±2.7 (87.9%) of them were females. Most of our participants were Single (89.8%). A total of 85.9% of the students had poor sleep quality. Those who had less than 6 Hours of sleeping per day had poor sleep quality by 92.2% and statistically affecting their sleep quality p value =0.000. There was no statistically significant relation between sleep quality and academic year or with Gender (p=0.139, p=0.263) respectively. There was no statistical correlation between Sleep quality and Nightmares or Snoring (p value =0.063, 0.055) respectively.Conclusions: Poor sleep quality was prevalent in all class years of the undergraduate medical course and more common between females. This study revealed high prevalence of poor sleep quality. Sleep educational programs, stress management courses and lifestyles modifications are required.