Objectives: This study aimed to assess knowledge, attitude and practice regarding breast cancer and its screening among women in King Khalid Armed Forces Hospital, Tabuk 2017. Methods: It was cross sectional study-facility based study carried out in Tabuk city including a random sample of women (336) aged 18 years and above attending family medicine clinic and women health center, King Khalid Armed Forces hospital throughout the period between 1 st of March and 30 of April, 2017. Breast cancer awareness measure (CAM) validated questionnaire was used to collect the data. Results: The age of almost one-third of them (34.2%) ranged between 30 and 39 years. Overall, the sufficient overall knowledge regarding breast cancer was observed among 13.1% of the participants. Multivariate logistic regression analysis revealed that older women were more likely to have insufficient knowledge about breast cancer compared to younger women (AOR=2.98, 95% CI=1. p=0.016 and AOR=2.83, p=0.049, respectively). Most of women (75.6%) rarely or never checked their breast , 8% did this at least once a month, 76.5% were not at all confident in noticing breast changes whereas only 1.2% of them were fairly confident ,27.4% saw a doctor about noticed breast changed whereas 44.9% of the women never noticed breast changes. Conclusion: Minority of adult women attending family medicine clinic and women health center, King Khalid Armed Forces hospital, Tabuk have sufficient knowledge of breast cancer. Most of them rarely or never checked their breast and not at all confident in noticing breast changes.