A creation of new water-soluble porphyrin-polymers having antibacterial properties is actual today because these substances can be used in a medicine and pharmacology. Therefore, the aim of this work is to obtain a water-soluble polyvinyl alcohol-based immobilizates containing dibromo-derivatives of meso-aryl porphyrins in a side chain of the polymer and the study of their bacterial activity towards Escherichia coli ATCC 25922, Candida albicans ATCC 885-653, Staphylococcus aureus ATCC 653. The bromination of 2-formyl-5,10,15,20-tetraphenylporphyrin and its zinc (II) complexes in the phenyl rings and in the β-positions of macroheterocycle was performed. 2-Formyl-10,15-(4',4'-dibromophenyl)-5,20-diphenylporphyrin and 2-formyl-dibromo-12,13-tetraphenylporphyrin were obtained. Porphyrin metalocomplexes were prepared by the complexation reaction of porphyrin dibromo-derivatives with zinc acetate. The purification of the porphyrin metalocomplexes was carried out by the column chromatography on silica gel, using chloroform as eluent. The structure of the compounds obtained was confirmed by electronic, IR and 1H NMR spectroscopy. Water-soluble porphyrin-polymers were prepared by covalent immobilization of polyvinyl alcohol based on the synthesized porphyrins and their metalocomplexes. The immobilization was carried out by acetalization reaction in an organic medium using 20% sulfuric acid as a catalyst. The immobilizates obtained are intensely colored solid polymer products which are soluble in water and dimethylformamide. Porphyrin weight content in a series of synthesized immobilizates and their immobilization molar degree were determined by electronic absorption spectra. The highest molar degree of porphyrin immobilization on polyvinyl alcohol is achieved at a fixation of 2-formyl-dibromo-12,13-tetraphenylporphyrin and zinc-2-formyl-10,15-(4',4'-dibromo-phenyl)-5,20-diphenylporphyrine on polyvinyl alcohol. It was 0.90 and 0.86, respectively. The influence of the synthesized porphyrin-polymers on Escherichia coli АТСС 25922, Candida albicans АТСС 885-653, Staphylococcus aureus АТСС 653 was investigated by diffusional method of antibacterial activity determining. An investigation of the biological activity of water-soluble immobilizates showed that the polymers and their prepared porphyrin zinc (II) complexes have antibacterial activity against the studied cultures. Significant effect on the inhibition of given cultures have immobilizate containing zinc-2-formyl-10,15-(4',4'-dibromophenyl)-5,20-diphenylporphyrine. For citation:Pechnikova N.L., Alopina E.V., Кuznetsov O.Yu., Ageeva T.A., Koifman O.I. Synthesis and study of antibacterial activity of bromine derivatives of porhyrin polymers and their zinc complexes. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 2. P. 52-59.

Theβ-diversity of fleas parasitic on small mammals in 45 regions of the Palearctic was partitioned into species [species contributions toβ-diversity (SCBD)] and site ( = assemblage) contributions [local contributions toβ-diversity (LCBD)]. We asked what are the factors affecting SCBD and LCBD and tested whether (a) variation in ecological, morphological, life history and geographic traits of fleas can predict SCBD and (b) variation in flea and host community metrics, off-host environmental factors, host species composition of flea assemblages can predict LCBD. We used spatial variables to describe geographic distribution of flea assemblages with various LCBD values. SCBD significantly increased with an increase in abundance and a decrease in phylogenetic host specificity of a flea as well as with size and latitude of its geographic range, but was not associated with any morphological/life history trait. LCBD of flea assemblages did not depend on either flea or host species richness or environmental predictors, but was significantly affected by compositional uniqueness ( = LCBD) of regional host assemblages and variables describing their species composition. In addition, variation in LCBD was also explained by broad-to-moderate-scale spatial variables. We conclude that SCBD of fleas could be predictedviatheir ecological and geographic traits, whereas LCBD of their assemblages could be predictedviahost composition.

It was established that microwave irradiation solvent-free processing of 2,6- diaminopyridine or 1,3-phenylenediamine with phthalonitrile or 4-tert-butylphthalonitrile led to corresponding hemiporphyrazines with sufficiently high yields and a huge reduction in the time required for synthesis, from 8–12 h to 20 min. The data of IR and UV-vis spectroscopies and elemental analysis of the final products were found to be similar to those described in literature. The obtained hemiporphyrazines were characterized by 1H and [Formula: see text]C NMR data. We applied the Knudsen effusion method with mass spectrometric control of vapor composition. The mass spectrometric investigations established that the macrocyclic compounds give a stable stream of particles and their enthalpies of sublimation were estimated by the second law of thermodynamics.