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& Two accurate and sensitive stability-indicating methods for the determination of rosuvastatin calcium in the presence of its acid degradation products are presented. The first method utilizes quantitative spectrodensitometric evaluation thin-layer chromatography (TLC) of rosuvastatin calcium in the presence of its acid degradation products, using ethyl acetate=methanol=ammonia (7:3:0.01, by volume) as a mobile phase. Chromatograms are scanned at 245 nm. This method analyzes rosuvastatin calcium in a concentration range of 0.6-3.4 lg=band with mean percentage recovery of 99.78 AE 1.42. The second method is a high-performance liquid chromatography (HPLC) method for the simultaneous determination of rosuvastatin calcium in the presence of its acid degradation products. The mobile phase consists of water=acetonitrile=methanol (40:40:20, by volume). The standard curve of rosuvastatin calcium shows a good linearity over a concentration range of 10-60 lg mL À1 with mean percentage recovery of 100.22 AE 0.86. These methods were successfully applied to the determination of rosuvastatin calcium in bulk powder, laboratory-prepared mixtures containing different percentages of the acid degradation products, and pharmaceutical dosage forms. The validity of results was assessed by applying standard addition technique. The results obtained were found to agree statistically with those obtained by a reported method, showing no significant difference with respect to accuracy and precision.

Survey and population dynamics were carried out in two regions, Abu-Abdalla village, Sedi Salem District and Salait village, Quallen district at Kafr El-Sheikh Governorate during two successive seasons from 2015to2017 on egyptian clover, lettuce, and cabbage. The survey revealed the existence of four species of land snails, Monacha cantiana, Succinea putris, Theba pisana and Cochlicella acuta were predominant on egyptian clover and two vegetables crops. The population densities of these land snail species were studied on soil, stems and leaves of studied plants. The results showed that the highest population was recorded on leaves under field of vegetable plants during spring seasons except cabbage at Abu Abdalla, Sedi Salem district in 2015 and 2016. T.pisana presented in Lettuce and and Cabbage on Abu-Abdella village and was absent on all vegetable crops on the second village. while M. cantiana ,C.acuta and S.putris snails were recorded with highest numbers on Egyptian clover. On the other hand, S. putris was in heavy infestation on lettuce and cabbage in the two regions. The damage caused by different snail species M. cantiana and S. putris was studied on Egyptian clover.

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