Background: A novel function for YajL, the prokaryotic homolog of the Parkinsonism-associated protein DJ-1. Results: YajL and DJ-1 form mixed disulfides with members of the thiol proteome. Conclusion: This covalent chaperone function supports their role in oxidative stress protection. Significance: There is an exciting encounter between the crucial cysteine 106 of these covalent chaperones and the oxidized cysteines of their substrates.
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