Uvod/cilj: Kokain je alkaloid iz lišća biljke Erythroxylym coca i Erythroxylym novogranatense. Unosi u organizam oralno, intranazalno, intravenski i inhalatorno, intragenitalno. Zloupotrebom kokaina može nastati subarahnoidalno i intracerebralno krvarenje. Cilj rada je prikazati koncentracije kokaina i benzoilekgonina u telesnim tečnostima i organima, učestalost subarahnoidalnog i intracerebralnog krvarenja i povezanost pomenutog krvarenja sa koncentracijama kokaina/benzoilekgonina. Metode: Analizirano je 26 obdukcionih nalaza u periodu od 2005. do 2018. godine sa ustanovljenim prisustvom kokaina i/ili benzoilekgonina. Uzeto je tkivo mozga za patohistološku analizu i krv iz femoralne vene, urin, želudačni sadržaj, mozak, bubreg i jetra sa žučnom kesom za toksikološko-hemijsku analizu. Rezultati: U istraživanju je učestvovalo 26 obdukovanih životnog doba od 23 do 56 (33,77±8,520) godina, Među njima je bilo 20/26 (75,92%) muškaraca i 6/26 (23,08%) žena. Toksikološkohemijskom analizom kokain u krvi je nađen kod 12/26 (46,15%), u urinu kod 15/26 (57,69%), i u mozgu kod 8/26 (30,77%) obdukovanih. Benzoilekgonin u krvi je nađen kod 20/26 (76,92%), u urinu kod 21/26 (80,77%) i u mozgu kod 10/26 (38,46%) obdukovanih. Subarahnoidalno krvarenje je ustanovljeno kod 10/26 (38,46%), intracerebralno krvarenje kod 18/26 (69,23 a subarahnoidalno i intracerebralno krvarenje zajedno kod 6/26 (23,07%) obdukovanih. Zaključak: U istraživanju je ustanovljeno da su subarahnoidalno i intracrebralno krvarenje bili česti kod ispitanika koji su koristili kokain. Intracerebralno (fokalno i perivaskularno) krvarenje bilo je češće. Koncentracije kokaina i benzoilekgonina u telesnim tečnostima i organima kod obdukovanih kod kojih je ustanovljeno intracerebralno i subarahnoidalno krvarenje su statistički značajno veće nego kod onih koji nisu imali krvarenja. Povezanost između subarahnoidnog i intracerebralnog krvarenja i koncentracije kokaina u krvi bila je umerene jačine. Između subarahnoidalnog i intracerebralnog krvarenja i koncentracija benzoilekgonina u više uzoraka postoji jaka povezanost.

In our population the length of long bones of the forearm and the leg are characterized by various degree of correlation with body height. The formulae that we set, make less distinction between the measured and the calculated body height as compared with the Trotter-Gleser formulae. We do hope that their implementation will facilitate identification of sceletal remains in our population.

Introduction. During the last few years, intravenous lipid emulsions have been effectively used in treatment of acute poisonings with lipophilic substances, including verapamil. Case report. A 37-year-old women presented 1 hour after ingestion of 2.8 g verapamil with hypotension and complete heart block. Because of the applied standard therapy failure and further patients impairment, Intralipid ® 20% was used. Sinus rhythm was restored, arterial blood pressure increased and verapamile concentrations, both total and free decreased. Conclusion. Intravenous lipid emulsion can be important in treatment of severe acute intoxication and cardiotoxicity caused by verapamil.Uvod. Poslednjih godina intravenske emulzije masti uspešno se koriste u terapiji akutnih trovanja lipofilnim supstancama, uključujući i verapamil. Prikaz bolesnika. Prikazana je 37godišnja pacijentkinja primljena jedan sat nakon ingestije 2,8 g verapamila. Na prijemu je bila hipotenzivna, sa kompletnim srčanim blokom. Zbog izostanka efekta primenjene standardne terapije i daljeg pogoršanja stanja pacijentkinje primenjen je Intralipid ® 20%, nakon čega je uspostavljen sinusni ritam. Zabeležen je porast arterijskog pritiska, uz smanjenje koncentracije verapamila, kako ukupnog, tako i slobodne frakcije leka. Zaključak. Intravenske emulzije masti mogu zauzeti važno mesto u terapiji teške akutne intoksikacije i kardiotoksičnosti uzrokovane verapamilom.

Introduction. Meadow saffron (Colchicum autumnale L.) is a perennial herbaceous plant belonging to the Lily family (Liliacea). It is similar to the edible wild garlic (Allium ursinum L.). Toxic substance in meadow saffron is alcaloid colchicine. Colchicine poisoning is a very dangerous condition, which can lead to fatal outcome. Case report. A 50-years-old male was addmited to the hospital complaining of weakness, abdominal pain, nausea, vomiting and having diarrhea without blood. Day before he ate two plants thinking they were wild garlic and seven hours after ingestion he felt first symptoms. During the course of the hospital stay, he had gastroenterocolitis, acute renal faliure, hepatic leasion and cardiorespiratory insufficiency with fatal outcome. Post-mortem examination reveled: brain oedema, lung oedema and congestion, heart weighing 700 g with ventricular hypertrophy, myocardial fibrosis, liver congestion and steatosis, spleen congestion, pancreatic fibrosis. Organs' sections were taken for pathohistological analysis. Body fluids and parts of organs were toxicologically analyzed. Pathohistological findings: brain oedema, diffuse perivascular and interstitial myocardial fibrosis, myocardial haemorrhage, lungs congestion and oedema, microvesicular and macrovesicular liver steatosis, centrilobular liver necrosis, lymphocytic inflammatory infiltrate in liver portions, red pulp congestion of the spleen, kidney congestion and interstitial bleeding, coagulation necrosis of the proximal tubules of the kidney. Toxicological analysis showed colchicine in blood-0.011 mg/L, urine-0.051 mg/L, liver with gallbladder-0.007 mg/kg, kidney-0.008 mg/kg. Conclusion. Ingestion of the meadow saffron can lead to poisoning with fatal outcome due to colchicine alcaloid. Colchicine intoxication should be suspected in patients with gastrointestinal symptoms after consuming wild plants.