Expedient Trimethylaluminum-Promoted One-Pot Synthesis of Functional Heteroaromatic and Carbocyclic Trifluoroethylamines. -The new method includes the generation of a trifluoromethyl-ketimine from corresponding (hetero)aryl trifluoromethyl ketones and an aniline derivative. Next, the ketimine is subsequently converted into the trifluoroethylamines in a one-pot reaction by addition of borane-methyl sulfide complex. -(ALLENDOERFER, N.; SUDAU, A.; BRAESE*, S.; Adv. Synth. Catal. 352 (2010) 16, 2815-2824, http://dx.

The methodology, previously developed by Gosh and Zajc, is modified and allows a high diversity of products which are of interest in medicinal chemistry.

Starting from commercially available anthranilic acid derivatives, a new short synthesis of the title compounds (V) is described.