MRSA is Staphylococcus aureus bacteria  that is resistant to methicillin and certain antibiotics. These organisms live as commensal bacteria that are transmitted in communities and health facilities which cause various health problems. Patients who develop antibiotic resistance have a worse clinical condition and many lead to death. The purpose of this study was to compare MSSA and MRSA against fluoroquinolone group and vancomycin antibiotics.  Specimens derived from various clinical samples sent to microbiology laboratories FMUI for the period 2018-2019. Gram staining and culture is carried out according to the procedure of each colony that grows on the medium. Followed by identification using the automatic machine Vitek 2®. A total 62 isolates, 58 were MSSA and the others were MRSA (6.45%).  MSSA patients  are in the age range 1 -  >50 years, dominant in men while MRSA is in the age range 16 – 30 and  >50 years, dominant in women. The sensitivity of the fluoroquinolone group and vancomycin  of antibiotics to MSSA was 100% whereas for MRSA  it was 50 %  to fluoroquinolone group and 100% to vancomycin. Vancomycin can be the antibiotic of choice for the management of infections by MRSA bacteria.