Metallic nano particle is nano sized metals with dimensions (length, width, thickness) within the size range of 1-100nm. In 1857, Faraday first investigated the existence of metallic nano particles in solution. In 1908, Mie gave a quantitative explanation of their colour. Today these nano materials can be prepared and modified with various chemical functional groups which allow them to bind with antibodies, ligands and drugs. Metallic nanoparticles give wide range of application in therapeutic area, biotechnology, vehicles for gene and drug delivery. This review summarizes the properties, advantages, disadvantages and characteristics of metal nanomaterials. This review also highlights on how metallic nanomaterials work as a catalyst and why is it necessary for stabilization. It provides the readers, detailed information on the synthesis by various methods, characterization, with particular focus on therapeutic application along with potential side effects and their future perspective. Recent headway had opened the way to site-specific targeting and drug delivery by these metallic nanoparticles.

Drug delivery to the brain is challenging because of the low permeability of blood–brain barrier, and therefore, optimum concentration of chemotherapeutics in the target area specifically for glioblastoma, an aggressive brain tumor, opens a new path of research. To achieve the goal, the oral alkylating agent temozolomide was incorporated into niosomes, and the surface was modified with chlorotoxin, a small 36 amino acid peptide discovered from the venom of scorpion Leiurus quinquestriatus. Active targeting using nanosized particles facilitates an increase in the accumulation of drugs in the cerebri by 3.04-folds. Temozolomide-loaded niosomes were prepared using conventional thin-film hydration method and characterized. Niosomes coated with chlorotoxin were produced with the size of 220 ± 1.45 nm with an entrapment efficiency of 79.09 ± 1.56%. Quantitative tissue distribution studies indicate enhanced permeation of the drug into the brain because of surface modification with less deposition in the highly perfused organs.

Diabetic neuropathy has been defined as the presence of symptoms and/or signs of peripheral nerve dysfunction in diabetics after exclusion of other causes (e.g. hereditary, traumatic, compressive, metabolic, toxic, nutritional, infectious, immune mediated, neoplastic and secondary to other systemic illnesses). Peripheral neuropathy is characterized by diffuse damage to the peripheral nerve fibers. Chronic diabetes mellitus is associated with various complications such as retinopathy, neuropathy, nephropathy, cardiomyopathy, vasculopathy, dermatopathy and encephalopathy. DPN as a 'symmetrical, length-dependent sensorimotor polyneuropathy attributable to metabolic and micro-vessel alterations resulting from chronic hyperglycemia and cardiovascular risk covariates. Diabetic sensorimotor polyneuropathy (DSPN), the most common type of diabetic or disease

The quick growth of electrochemical energy storage which are applied in various fields like electronics for portable consumer, vehicles of hybrid electrics and also for power and energy management in an industrial scale. Electrochemical capacitors (ECs) is the decisive of electrochemical energy storage systems which can supply an

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