A synthetic route to ecteinascidin 743 has been established
via
an intramolecular cascade Heck reaction to construct the diazabicyclo[3.3.1]nonane
skeleton while controlling the two contiguous stereogenic centers.
The strategically formed five-membered ring was oxidatively cleaved
to generate a dialdehyde intermediate, from which the B ring of ecteinascidin
743 was constructed.
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