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Diabetes is the cause for nearly 80% of the non-traumatic amputation. Amputation could be described as the removal of a body extremity by surgery. The patients post diabetic foot amputations are exposed to many physical, social and psychological problems which affect on his life. Aim of the study: to assess the bio-psychosocial needs of patients with post diabetic foot amputation. Research design: A descriptive exploratory design was utilized. Subjects: 50 patients admitted in diabetic foot clinic. Setting: outpatient clinic in Beni-Suef health insurance hospital at Beni-Suef city Egypt was selected for this study. Tools for data collection: Demographic data assessment tool, medical data assessment tool, patients' knowledge assessment interview questionnaire, bio psychosocial needs assessment interview questionnaire and diabetic foot reported practice checklist. Results: 56% of the studied patients had unsatisfactory of total knowledge regarding diabetes mellitus and diabetic foot amputation. 72% of the studied patients had unsatisfactory self care of non-amputated foot and 78% of them had satisfactory self care of amputated foot. While regarding physical problems, 24% of the studied patients had moderate pain and 52% of them need assistance with daily living activities regarding bathing, toileting and moving. Also, 48% of them need assistance regarding functional performance. A regard to the psychological needs, 100% of the studied patients suffered psychosomatic symptoms, GIT symptoms and behaviors symptoms on speech. Furthermore, in relation to the social needs, 32% of the studied patients stated that they had mild social needs parameters as feeling financial burden about cost of treatment. Conclusion: more than half of studied patients suffered from many physical, psychological and social problems post diabetic foot amputation. Recommendation: Rehabilitation programs for patients with diabetic foot amputation must be implemented through the collaboration of various rehabilitation team members.

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