The study was designed to explore the effect of Sanguinarine phytobiotic and sodium butyrate on growth performance, hemato-biochemical and immunological profile of healthy broiler chickens. Ninety, one-day old healthy broiler chicks were divided into three equal groups. Group 1 of healthy chicks was kept as a control group, group 2 in which the broilers received 2 mL/L sodium butyrate and group 3 in which the broilers received 1 g/10 L phytobiotic (Sangrovit) ® . At the end of drug administration, two blood samples were collected from each group for hematobiochemical and immunological parameters. The results revealed that, broiler chicks received sodium butyrate and Sanguinarine phytobiotic showed a significant increase in body weight (2250. 64 and 2206.23 g versus 2005.43g in control), weight gain (966.19 and 945.66g versus 855.20g in control), feed consumption and feed conversion rate (1.72 and 1.75 versus 1.85 in control). Hemato-biochemical and immunological analysis revealed a significant increase in total erythrogram (RBCs 4.98 and 5.22 versus 4.37 in control) and leukogram (14.33 and 14.64 versus 11.26 in control), phagocytosis and phagocytic percent (61.23 and 62.05 versus 58.68 in control), nitric oxide (20.34 and 20.48 versus 19.05 in control), hemagglutination inhibition titer against Newcastle disease virus (3.20 and 3.25 versus 2.03 in control), total protein (6.23 and 6.35 versus 5.67 in control) and albumin (3.25 and 3.55 versus 2.95 in control), with non-significant increase in total globulin, , , globulins, albumin/globulin ratio, liver enzymes; aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase; uric acid and creatinine levels. In conclusion, sodium butyrate and Sanguinarine phytobiotic induced improvement in growth performance, hemato-biochemical and immunological profile in healthy broiler chickens. They could be safely used as alternatives to antibiotics growth promoters in the commercial broiler diet to lower the risk of antibiotic residues in meat and to avoid the antibiotic resistance to the consumers.
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