This study conducted a clinical trial to evaluate the relieving effects of Saussurea lappa on migraine patients. The results showed that calcium and magnesium concentrations decreased significantly in patients while serotonin increased after two weeks of treatment with Saussurea lappa. The drug (Amitriptyline 20mg/day and Ibuprofen 400mg/day) decreased alkaline phosphatase level significantly, while Saussurea lappa had no effect on its level. This study found Saussurea lappa a safe and effective alternative therapeutic agent which indicated that this root could have an effect in relieving headaches (migraine).