Background: Measles is a feverish condition labeled among the most infectious viral illnesses in the globe. Despite the presence of a secure, accessible, affordable and efficient vaccine, measles continues to be a worldwide concern. Methods: This study uses machine learning and time series methods to assess factors that placed people at a higher risk of measles. This historical cohort study contained the Measles incidence in Markazi Province, the center of Iran, from April 1997 to February 2020. Logistic regression, linear discriminant analysis, random forest, artificial neural network, bagging, support vector machine, and naïve Bayes were used to make the classification. Zero-inflated negative binomial regression for time series was utilized to assess development of measles over time. Results: The prevalence of measles was 14.5% over the recent 24 years and a constant trend of almost zero cases was observed from 2002 to 2020. The order of independent variable importance were recent years, age, vaccination, rhinorrhea, male sex, contact with measles patients, cough, conjunctivitis, ethnic, and fever. Younger age, less probability of contact and no fever is associated with less odds of zero cases. Only 7 new cases were forecasted for the next two years. Bagging and random forest were the most accurate classification methods. Conclusion: Even if the numbers of new cases are almost zero during the recent years, it has been showed that age and contact are responsible for non-occurrence of measles. October and May are prone to have new cases for 2021 and 2022.

Background: Measles is a feverish condition labeled among the most infectious viral illnesses in the globe. Despite the presence of a secure, accessible, affordable and efficient vaccine, measles continues to be a worldwide concern. Methods: This epidemiologic study used machine learning and time series methods to assess factors that placed people at a higher risk of measles. The study contained the measles incidence in Markazi Province, the center of Iran, from Apr 1997 to Feb 2020. In addition to machine learning, zero-inflated negative binomial regression for time series was utilized to assess development of measles over time. Results: The incidence of measles was 14.5% over the recent 24 years and a constant trend of almost zero cases were observed from 2002 to 2020. The order of independent variable importance were recent years, age, vaccination, rhinorrhea, male sex, contact with measles patients, cough, conjunctivitis, ethnic, and fever. Only 7 new cases were forecasted for the next two years. Bagging and random forest were the most accurate classification methods. Conclusion: Even if the numbers of new cases were almost zero during recent years, age and contact were responsible for non-occurrence of measles. October and May are prone to have new cases for 2021 and 2022.