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This presentation discloses a one-pot synthesis of a series of spiropyrroloquinoline isoindolinone and spiropyrroloquinoline aza-isoindolinone scaffolds. The reaction proceeds by the combination of a Ugi four-component reaction (4CR) and two intramolecular cyclizations under metal-free conditions. The proof of the structures relies on analytical investigation and X-ray crystallography.

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This presentation describes the successful synthesis of novel tetrazole‐based quinoline and tetrahydro‐1H‐β‐carboline derivatives via one‐pot multicomponent reactions in moderate to good yields. These reactions have presumably proceeded through Ugi‐azide or Ugi‐azide/Pictet–Spengler processes, respectively.