An 11‐year follow‐up of a patient with malignant pheochromocytoma of the organ of Zuckerkandl (M.P.O.Z.) is reported. The long survival was probably due to treatment by α and β blocking agents, preventing a cardiovascular catastrophy. The patient ultimately succumbed to diffuse metastatic spread. Radiologic and cytotoxic treatment did not have any appreciable effect on the course of the disease.

been under the treatment of sulfasalazine and he has remained asymptomatic. Conclusion Calciphylaxis may appear without renal failure and hyperparathyroidism. Long-term steroid using in RA patients may lead to calciphylaxis. Acquired protein S deficiency may contribute to this process. AB0094 PREVALENCE OF TWIN BIRTHS IN BEHÇET'S DISEASE (BD)

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Methods 14 patients with active rheumatoid arthritis and unresponsive to at least 3 DMARDs were treated with methotrexate and infliximab. Before infliximab infusion, weeks 0, 2,6,14 and 22, a physical examination, DAS 28 and blood test, which included RF, ANA, immunoglobulin quantification C3 and C4 were done. Results At the baseline visit 5/14 (35,71%) patients had positive ANA test,2 (1/40),1 (1/80),1 (1/160), 1 (1/640). After the fifth infusion 8/14 (57,14%) had a positive ANA test. Three patients who initially were ANA negative showed a titre of 1/160,1/320 and 1/640. Three out of 5 patients which previously had a positive test, showed an increase in the ANA titre,1/40 to 1/80,1/40 to 1/320 and 1/640 to 1/1280. After the fourth infusion of infliximab, all patients with ANA positive had a Crithidia test performed. In all cases anti DNA were negative. Conclusion In our experience, treatment with infliximab has shown an increase of the ANA titre in 21,42% of the patients. On the other hand, 21,4% of the patients with a previous negative test for ANA had a positive test after the fourth infusion. All cases were negative for anti-DNA antibodies.