ResumoIntrodução: O Lúpus Eritematoso Sistêmico (LES) caracteriza-se pela formação e deposição de autoanticorpos contra os mais diversos órgãos;Objetivo:Descrever a morbidade, o dano e o prognóstico de pacientes com LES internados pela primeira vez. comprometimento em órgãos nobres, como rins e sistema nervoso central. Palavras-chave:Lúpus eritematoso sistêmico. Hospitalização. Prognóstico. AbstractIntroduction: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibodies that attack the patient's body.Early diagnosis of this disease is an important factor in improving patient survival. Objective: The aim of this study is to describe the morbidity, the damage and the prognosis of the SLE patients prime hospitalization. Methodology: of SLE patients randomized in the outpatient unit Dr. César Cals General Hospital. These patients had agreed on signing a paper giving their consent for submission to the treatment of this disease. Results: All 30 SLE patients were female and the average age was about 29.8 years.were admitted for establishing diagnosis and only 19 reported taking corticosteroids with or without chloroquine. 66.7% were in frank disease activity, with renal involvement being the most prevalent; renal damage also stood out as the most common, followed by the central nervous 36.7% were readmitted, six due to active nephritis and 3 developed terminal chronic renal failure. Conclusions: These SLE patients series prime of the disease and getting the diagnosis, already presented commitment in vital organs, such as kidneys and central nervous system.