Retinoblastoma is one of the common intraocular malignancy in childhood. It’s incidence varies between 1 in 3300 to1 in 20,000 live birth. Retinal dysplasia is a rare disorder which can mimic retinoblastoma. Retinal dysplasia is a rare cause of childhood leucocoria, which can cause considerable diagnostic difficulty in the differentiation of benign and malignant intraocular pathologies Enucleation is often required for both these conditions. In this series we are discussing 4 cases of enucleated eyeball. Out of these 4 cases three cases were of retinoblastoma.4 case was done for post traumatic phthysis bulbi. In this case series we are discussing diagnostic and prognostic indicators of Retinoblastoma as well as retinal dysplasia.