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Objectives:This study was aimed to explore the antipyretic and anti-inflammatory effects of n-butanol etract of Atractylis flava Desf (A. flava) using experimentally induced inflammation and pyrexia models in rats. Methods: In the acute toxicity study, a single oral dose of 2000 mg/kg of n-butanol extract was given to rats. The antipyretic activity was evaluated using brewer's yeast induced pyrexia in rats. In addition, albumin induced rat paw edema was performed by the injection of 100 µL undiluted fresh egg albumin to assess the anti-inflammatory effects of the plant. Results: The results of the present study revealed that n-butanol extract of A. flava significantly (P<0.001) reduced fresh egg albumin-induced rat paw edema and also inhibited fever significantly in brewer's yeast induced pyrexia. Conclusion: The results of the present study indicated that A. flava possesses antipyretic and anti-inflammatory activity in the models studied.