The management of knowledge assets is crucial for gaining competitive advantage and has a huge strategic importance for the firms. Knowledge management has become one of the emerging fields in today's research world and has turned out to be a major concern for the organizations as it plays a crucial role in the growth and development of the organization. Knowledge management is a new concept that is why it is gaining increased attention among small and large organizations. In this study three important knowledge management practices are discussed and the necessary insights regarding knowledge management processes and their positive impacts within an organization are provided. The study also brings forth the relationships which knowledge management processes have with radical innovation in small and medium enterprises. The explanatory method of research and quantitative type of research to test the hypothesis of research was used to carry out the study and survey type was involved by using questionnaire. The knowledge management and innovation instruments were adapted from previous researchers. This study's target population consisted of small and medium-sized enterprises that included service sectors in Quetta, Balochistan. A convenient sampling was applied to collect the necessary data from SMEs. A total of 850 firms were communicated and requested to participate in this survey but 300 (35.6% response rate) accepted to fill out the survey questionnaire. The study utilized structural equation modelling to examine numerous complex cause and effect relationships between variables. The results indicate a positive association between Knowledge management processes and radical innovation. The positive link between Knowledge management processes and innovation indicates the importance and value of knowledge management in achieving competitive advantage through innovation.

SIGIRR has been described as a negative regulator of several IL-1R/TLR family members and has been implicated in several inflammatory disease conditions. However, it is unknown whether it can suppress IL-36 family cytokines, which are members of the broader IL-1 superfamily that have emerged as critical orchestrators of psoriatic inflammation in both humans and mice. In this study, we demonstrate that SIGIRR is downregulated in psoriatic lesions in humans and mice, and this correlates with increased expression of IL-36 family cytokines. Using Sigirr−/− mice, we identify, for the first time (to our knowledge), SIGIRR as a negative regulator of IL-36 responses in the skin. Mechanistically, we identify dendritic cells and keratinocytes as the primary cell subsets in which IL-36 proinflammatory responses are regulated by SIGIRR. Both cell types displayed elevated IL-36 responsiveness in absence of SIGIRR activity, characterized by enhanced expression of neutrophil chemoattractants, leading to increased neutrophil infiltration to the inflamed skin. Blockade of IL-36R signaling ameliorated exacerbated psoriasiform inflammation in Sigirr−/− mice and inhibited neutrophil infiltration. These data identify SIGIRR activity as an important regulatory node in suppressing IL-36–dependent psoriatic inflammation in humans and mice.

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