A series of novel tetrazole scaffolds containing flavones and flavanones have been synthesized under conventional, ultrasonic and microwave irradiation methods. All the newly synthesized compounds were characterized by IR, NMR and Mass spectral analysis. Furthermore, the title compounds were screened in vitro antimicrobial activity against bacteria such as Staphylococus aureus, Bacillus subtilis, Klebsiella pneumoniae and Escherichia coli as well as fungi such as Aspergillus niger, Aspergillus flavus and Fusarium oxysporum. Some of the compounds showed good activity compared to standard drugs against all pathogenic bacteria and fungi.

An environmentally friendly method has been developed for substituted (E)-(3-(4-(1H-tetrazole-5yl)styryl)benzofuran-2-yl)([1,1'-biphenyl]-4-yl)methanone scaffolds by Suzuki cross-coupling reaction in an aqueous medium under both microwave irradiation and conventional heating methods. The structures of the synthesized scaffolds were characterized by IR, NMR, and mass spectral analysis. Furthermore, the synthesized scaffolds were screened for their in-vitro antibacterial, antifungal activities and most of the scaffolds exhibited better activity compared to standard drugs.