Limb-girdle muscular dystrophies (LGMDs) are a heterogeneous group of rare genetic disorders, characterized by progressive weakness and muscle wasting. Currently, more than 27 different muscular disorders are identified as subtypes of LGMDs. Derived from the inheritance manners, LGMDs were classified into two main types: LGMD type 1 (autosomal dominant: AD) and LGMD type 2 (autosomal recessive: AR). 1 LGMD2 shows a more common distribution, with a prevalence of 1: 15,000, than LGMD1 (<10% of all LGMD cases). 2 Moreover, LGMD2 has been investigated to be associated with mutations from a group of sarcoglycanopathies genes such as SGCG, SGCA, SGCB, SGCD genes, which cause several subtypes of LGMD2 including LGMD2C to F, respectively.