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Background:The H ϩ /2e Ϫ stoichiometry of complex I has been questioned based on recent crystal structures.

Background: Small molecule MEK1/2 inhibitors are designed to block ERK1/2-mediated signaling and inhibit proliferation. Results: Novel instrumentation which measures cellular respiratory chain function found that four structurally distinct MEK1/2 inhibitors acutely affected mitochondrial bioenergetics. Conclusion:The anti-mitochondrial effects of MEK1/2 inhibitors determined proliferative potential. Significance: Impaired mitochondrial metabolism following MEK1/2 inhibition must be considered when using small molecule inhibitors to define this signaling pathway.

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