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Peptides U 0400 Concise and Efficient Synthesis of Highly Potent and Selective Dipeptidyl Peptidase II Inhibitors. -A more practical, shorter, high yielding route for the synthesis of the highly potent and selective DPP II inhibitors (IX) and (XII) starts from L-glutamine. -(RASHEED*, M. A.; NAMALA, R.; MANNE, N.; VANJIVAKA, S.; DHAMJEWAR, R.; BALASUBRAMANIAN, G.; Synth. Commun. 38 (2008) 2, 162-169; GVK Biosci., IDA, Hyderabad 500 076, India; Eng.) -H. Toeppel 26-192

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The hydrazide-hydrazone analogs 4a-4l is described via the condensation of 3,4,5-trimethoxybenzohydrazide 3 with various aromatic and hetero aromatic aldehydes a-l. Various spectroscopic techniques viz., ( 1 H NMR, 13 C NMR, IR and MS) were utilized to determine the structures of synthesized compounds. These compounds were evaluated for antibacterial, antifungal screening against S.aureus, S.pyogenes, E.coli, P.aeruginosa, Aspergillus niger and Candida albicans (Fungal strains). The results revealed that most of the hydrazone derivatives exhibited significant antibacterial activity. Furthermore, the synthesized hydrazone derivatives were found to exhibit significant antidiabetic activity when compared to insulin.